TBC1 domain family member 23 (TBC1D23)
Homo sapiens — UniProt Q9NUY8
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 23 (TBC1D23) is a protein from Homo sapiens identified by UniProt accession Q9NUY8, 699 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9NUY8; gene symbol TBC1D23.
- Organism: Homo sapiens.
- Length: 699 amino acids.
- Top disease associations (Open Targets): Non-syndromic pontocerebellar hypoplasia, pontocerebellar hypoplasia and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 23 |
|---|---|
| UniProt accession | Q9NUY8 |
| Gene | TBC1D23 |
| Organism | Homo sapiens |
| Length | 699 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- Non-syndromic pontocerebellar hypoplasia · score 0.71
- pontocerebellar hypoplasia · score 0.46
- genetic disorder · score 0.41
- Intellectual disability · score 0.37
- neurodegenerative disease · score 0.34
- BMI-adjusted waist circumference · score 0.14
- refractive error · score 0.08
- non-small cell lung carcinoma · score 0.07
- drug use measurement · score 0.06
- facial morphology measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUY8-F1 | alphafold | PREDICTED | 80.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUY8.
Amino-acid sequence (699 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D23?
The strongest Open Targets associations for TBC1D23 are Non-syndromic pontocerebellar hypoplasia, pontocerebellar hypoplasia, genetic disorder, Intellectual disability and neurodegenerative disease.
How long is the TBC1D23 protein?
The Homo sapiens TBC1D23 protein (UniProt Q9NUY8) is 699 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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