Transmembrane protein 140 (TMEM140)

About Transmembrane protein 140

Transmembrane protein 140 (TMEM140) is a protein from Homo sapiens identified by UniProt accession Q9NV12, 185 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Transmembrane protein 140
UniProt accession	Q9NV12
Gene	TMEM140
Organism	Homo sapiens
Length	185 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.23
red blood cell density measurement · score 0.12
monocyte count · score 0.12
erythrocyte count · score 0.12
monocyte percentage of leukocytes · score 0.08
hematocrit · score 0.04
facial morphology measurement · score 0.04
neoplasm · score 0.04
hemoglobin measurement · score 0.03
response to vaccine · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV12-F1	alphafold	PREDICTED	87.08	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NV12.

Amino-acid sequence (185 residues)

MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards