S-acyl fatty acid synthase thioesterase, medium chain (OLAH)
Homo sapiens — UniProt Q9NV23
Data last refreshed: (UniProt release unknown)
Key facts
S-acyl fatty acid synthase thioesterase, medium chain (OLAH) is a protein from Homo sapiens identified by UniProt accession Q9NV23, 265 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q9NV23; gene symbol OLAH.
- Organism: Homo sapiens.
- Length: 265 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, preeclampsia and hereditary persistence of fetal hemoglobin-sickle cell disease syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | S-acyl fatty acid synthase thioesterase, medium chain |
|---|---|
| UniProt accession | Q9NV23 |
| Gene | OLAH |
| Organism | Homo sapiens |
| Length | 265 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.08
- preeclampsia · score 0.07
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.07
- fetal growth restriction · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- Sepsis · score 0.06
- hemoglobin D disease · score 0.06
- delta-beta-thalassemia · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NV23-F1 | alphafold | PREDICTED | 90.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NV23.
Amino-acid sequence (265 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OLAH?
The strongest Open Targets associations for OLAH are Blackfan-Diamond anemia, preeclampsia, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome, fetal growth restriction and alpha thalassemia-intellectual disability syndrome type 1.
How long is the OLAH protein?
The Homo sapiens OLAH protein (UniProt Q9NV23) is 265 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NV23 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NV23 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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