S-adenosyl-L-methionine-dependent tRNA…

About S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) is a protein from Homo sapiens identified by UniProt accession Q9NV66, 732 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
UniProt accession	Q9NV66
Gene	TYW1
Organism	Homo sapiens
Length	732 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

protein measurement · score 0.10
body weight · score 0.07
hemoglobin E-beta-thalassemia syndrome · score 0.05
hemoglobin D disease · score 0.04
DNA methylation · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
hemoglobin E disease · score 0.03
dominant beta-thalassemia · score 0.03
gait measurement · score 0.03
congenital dyserythropoietic anemia type 4 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV66-F1	alphafold	PREDICTED	80.26	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NV66.

Amino-acid sequence (732 residues)

MDPSADTWDL FSPLISLWIN RFYIYLGFAV SISLWICVQI VIKTQGKNLQ EKSVPKAAQD LMTNGYVSLQ EKDIFVSGVK IFYGSQTGTA KGFATVLAEA VTSLDLPVAI INLKEYDPDD HLIEEVTSKN VCVFLVATYT DGLPTESAEW FCKWLEEASI DFRFGKTYLK GMRYAVFGLG NSAYASHFNK VGKNVDKWLW MLGAHRVMSR GEGDCDVVKS KHGSIEADFR AWKTKFISQL QALQKGERKK SCGGHCKKGK CESHQHGSEE REEGSHEQDE LHHRDTEEEE PFESSSEEEF GGEDHQSLNS IVDVEDLGKI MDHVKKEKRE KEQQEEKSGL FRNMGRNEDG ERRAMITPAL REALTKQGYQ LIGSHSGVKL CRWTKSMLRG RGGCYKHTFY GIESHRCMET TPSLACANKC VFCWRHHTNP VGTEWRWKMD QPEMILKEAI ENHQNMIKQF KGVPGVKAER FEEGMTVKHC ALSLVGEPIM YPEINRFLKL LHQCKISSFL VTNAQFPAEI RNLEPVTQLY VSVDASTKDS LKKIDRPLFK DFWQRFLDSL KALAVKQQRT VYRLTLVKAW NVDELQAYAQ LVSLGNPDFI EVKGVTYCGE SSASSLTMAH VPWHEEVVQF VHELVDLIPE YEIACEHEHS NCLLIAHRKF KIGGEWWTWI DYNRFQELIQ EYEDSGGSKT FSAKDYMART PHWALFGASE RGFDPKDTRH QRKNKSKAIS GC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1)