Septin-11 (SEPTIN11)

About Septin-11

Septin-11 (SEPTIN11) is a protein from Homo sapiens identified by UniProt accession Q9NVA2, 429 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Septin-11
UniProt accession	Q9NVA2
Gene	SEPTIN11
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.48
platelet component distribution width · score 0.36
mean platelet volume · score 0.35
protein measurement · score 0.29
brain volume measurement · score 0.27
autosomal recessive cerebellar ataxia · score 0.12
hepatocellular carcinoma · score 0.08
neoplasm · score 0.07
emphysema pattern measurement · score 0.06
monocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NVA2-F1	alphafold	PREDICTED	81.72	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVA2.

Amino-acid sequence (429 residues)

MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET GIGKSTLMDT LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD TVGFGDQINK DDSYKPIVEY IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP IIAKADTIAK NELHKFKSKI MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST EEVKIGNKMA KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK EKEAELKEAE KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVNNFQKKKA AAQLLQSQAQ QSGAQQTKKD KDKKNASFT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards