Ubiquitin carboxyl-terminal hydrolase 40 (USP40)
Homo sapiens — UniProt Q9NVE5
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 40 (USP40) is a protein from Homo sapiens identified by UniProt accession Q9NVE5, 1235 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9NVE5; gene symbol USP40.
- Organism: Homo sapiens.
- Length: 1235 amino acids.
- Top disease associations (Open Targets): bilirubin measurement, mathematical ability and aspartate aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 40 |
|---|---|
| UniProt accession | Q9NVE5 |
| Gene | USP40 |
| Organism | Homo sapiens |
| Length | 1235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.60
- mathematical ability · score 0.29
- aspartate aminotransferase measurement · score 0.25
- adolescent idiopathic scoliosis · score 0.22
- bone density · score 0.22
- urate measurement · score 0.22
- cognitive decline measurement · score 0.18
- hemoglobin measurement · score 0.15
- psoriasis · score 0.14
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVE5-F1 | alphafold | PREDICTED | 76.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVE5.
Amino-acid sequence (1235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP40?
The strongest Open Targets associations for USP40 are bilirubin measurement, mathematical ability, aspartate aminotransferase measurement, adolescent idiopathic scoliosis and bone density.
How long is the USP40 protein?
The Homo sapiens USP40 protein (UniProt Q9NVE5) is 1235 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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