About 4'-phosphopantetheine phosphatase
4'-phosphopantetheine phosphatase (PANK4) is a protein
from Homo sapiens identified by UniProt accession
Q9NVE7, 773 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (135)
Diseases linked to this target (Open Targets).
- cataract 49 · score 0.46
- early-onset posterior polar cataract · score 0.37
- neurodegenerative disease · score 0.35
- body mass index · score 0.24
- FEV/FVC ratio · score 0.24
- IGF-1 measurement · score 0.14
- HbA1c measurement · score 0.11
- irritability measurement · score 0.11
- sex hormone-binding globulin measurement · score 0.10
- early-onset non-syndromic cataract · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9NVE7.
Amino-acid sequence (773 residues)
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY IEACLDFIKD HLVNTETKVI QATGGGAYKF KDLIEEKLRL KVDKEDVMTC LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ TNHPHIFPYL LVNIGSGVSI VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH LASRGQHSNV DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA LFLRHEGYLG AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ RARSGTFDLL EMDRLERPLV DLPLLLDPPS YVPDTVDLTD DALARKYWLT CFEEALDGVV KRAVASQPDS VDAAERAEKF RQKYWNKLQT LRQQPFAYGT LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG VVRSLDALGW EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA CNSGPALNDV THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL DLSRLDKGLA ALVRERGADL VVIEGMGRAV HTNYHAALRC ESLKLAVIKN AWLAERLGGR LFSVIFKYEV PAE
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