F-box only protein 28 (FBXO28)

About F-box only protein 28

F-box only protein 28 (FBXO28) is a protein from Homo sapiens identified by UniProt accession Q9NVF7, 368 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	F-box only protein 28
UniProt accession	Q9NVF7
Gene	FBXO28
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy 100 · score 0.71
neurodegenerative disease · score 0.46
undetermined early-onset epileptic encephalopathy · score 0.37
mean corpuscular volume · score 0.28
mean platelet volume · score 0.25
erythrocyte count · score 0.25
mean reticulocyte volume · score 0.21
mean corpuscular hemoglobin · score 0.19
genetic disorder · score 0.19
red blood cell density measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NVF7-F1	alphafold	PREDICTED	75.97	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVF7.

Amino-acid sequence (368 residues)

MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK ATEAIDSLRK SKRLRNRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards