Exonuclease 3'-5' domain-containing protein 2 (EXD2)
Homo sapiens — UniProt Q9NVH0
Data last refreshed: (UniProt release unknown)
Key facts
Exonuclease 3'-5' domain-containing protein 2 (EXD2) is a protein from Homo sapiens identified by UniProt accession Q9NVH0, 621 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9NVH0; gene symbol EXD2.
- Organism: Homo sapiens.
- Length: 621 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet count and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exonuclease 3'-5' domain-containing protein 2 |
|---|---|
| UniProt accession | Q9NVH0 |
| Gene | EXD2 |
| Organism | Homo sapiens |
| Length | 621 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.39
- platelet count · score 0.35
- neuroticism measurement · score 0.34
- tiredness measurement · score 0.25
- feeling "fed-up" measurement · score 0.24
- feeling emotionally hurt measurement · score 0.23
- emotional symptom measurement · score 0.23
- serum gamma-glutamyl transferase measurement · score 0.22
- insulin like growth factor measurement · score 0.21
- Abnormality of refraction · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVH0-F1 | alphafold | PREDICTED | 80.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVH0.
Amino-acid sequence (621 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXD2?
The strongest Open Targets associations for EXD2 are mean platelet volume, platelet count, neuroticism measurement, tiredness measurement and feeling "fed-up" measurement.
How long is the EXD2 protein?
The Homo sapiens EXD2 protein (UniProt Q9NVH0) is 621 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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