Trimethyllysine dioxygenase, mitochondrial (TMLHE)
Homo sapiens — UniProt Q9NVH6
Data last refreshed: (UniProt release unknown)
Key facts
Trimethyllysine dioxygenase, mitochondrial (TMLHE) is a protein from Homo sapiens identified by UniProt accession Q9NVH6, 421 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q9NVH6; gene symbol TMLHE.
- Organism: Homo sapiens.
- Length: 421 amino acids.
- Top disease associations (Open Targets): autism, Agenesis of corpus callosum and isolated cerebellar hypoplasia/agenesis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trimethyllysine dioxygenase, mitochondrial |
|---|---|
| UniProt accession | Q9NVH6 |
| Gene | TMLHE |
| Organism | Homo sapiens |
| Length | 421 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- autism · score 0.62
- Agenesis of corpus callosum · score 0.26
- isolated cerebellar hypoplasia/agenesis · score 0.26
- Cerebellar vermis hypoplasia · score 0.26
- mean corpuscular hemoglobin · score 0.25
- hemoglobin measurement · score 0.25
- mean corpuscular volume · score 0.25
- erythrocyte count · score 0.25
- hematocrit · score 0.25
- Red cell distribution width · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVH6-F1 | alphafold | PREDICTED | 89.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVH6.
Amino-acid sequence (421 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMLHE?
The strongest Open Targets associations for TMLHE are autism, Agenesis of corpus callosum, isolated cerebellar hypoplasia/agenesis, Cerebellar vermis hypoplasia and mean corpuscular hemoglobin.
How long is the TMLHE protein?
The Homo sapiens TMLHE protein (UniProt Q9NVH6) is 421 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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