Fanconi anemia group I protein (FANCI)
Homo sapiens — UniProt Q9NVI1
Data last refreshed: (UniProt release unknown)
Key facts
Fanconi anemia group I protein (FANCI) is a protein from Homo sapiens identified by UniProt accession Q9NVI1, 1328 residues long. MolForge cross-references it against 0 known binders and 260 disease associations.
- UniProt accession: Q9NVI1; gene symbol FANCI.
- Organism: Homo sapiens.
- Length: 1328 amino acids.
- Top disease associations (Open Targets): Fanconi anemia complementation group I, Fanconi anemia and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fanconi anemia group I protein |
|---|---|
| UniProt accession | Q9NVI1 |
| Gene | FANCI |
| Organism | Homo sapiens |
| Length | 1328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (260)
Diseases linked to this target (Open Targets).
- Fanconi anemia complementation group I · score 0.81
- Fanconi anemia · score 0.79
- acute myeloid leukemia · score 0.52
- myelodysplastic syndrome · score 0.46
- mitochondrial DNA depletion syndrome 4a · score 0.42
- Alpers syndrome · score 0.42
- head and neck malignant neoplasia · score 0.37
- Abnormal radial ray morphology · score 0.37
- Fanconi anemia complementation group A · score 0.30
- age at menopause · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVI1-F1 | alphafold | PREDICTED | 83.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVI1.
Amino-acid sequence (1328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FANCI?
The strongest Open Targets associations for FANCI are Fanconi anemia complementation group I, Fanconi anemia, acute myeloid leukemia, myelodysplastic syndrome and mitochondrial DNA depletion syndrome 4a.
How long is the FANCI protein?
The Homo sapiens FANCI protein (UniProt Q9NVI1) is 1328 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVI1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVI1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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