ADP-ribosylation factor-like protein 8B (ARL8B)
Homo sapiens — UniProt Q9NVJ2
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor-like protein 8B (ARL8B) is a protein from Homo sapiens identified by UniProt accession Q9NVJ2, 186 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q9NVJ2; gene symbol ARL8B.
- Organism: Homo sapiens.
- Length: 186 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, neoplasm and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor-like protein 8B |
|---|---|
| UniProt accession | Q9NVJ2 |
| Gene | ARL8B |
| Organism | Homo sapiens |
| Length | 186 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.17
- neoplasm · score 0.08
- cancer · score 0.07
- coxopodopatellar syndrome · score 0.03
- osteopathia striata-pigmentary dermopathy-white forelock syndrome · score 0.03
- insulin resistance · score 0.03
- breast cancer · score 0.03
- sleep duration · score 0.02
- triglyceride measurement · score 0.02
- Systemic lupus erythematosus · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVJ2-F1 | alphafold | PREDICTED | 92.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVJ2.
Amino-acid sequence (186 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARL8B?
The strongest Open Targets associations for ARL8B are alkaline phosphatase measurement, neoplasm, cancer, coxopodopatellar syndrome and osteopathia striata-pigmentary dermopathy-white forelock syndrome.
How long is the ARL8B protein?
The Homo sapiens ARL8B protein (UniProt Q9NVJ2) is 186 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVJ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVJ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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