Guanine nucleotide-binding protein-like 3-like protein (GNL3L)
Homo sapiens — UniProt Q9NVN8
Data last refreshed: (UniProt release unknown)
Key facts
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) is a protein from Homo sapiens identified by UniProt accession Q9NVN8, 582 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9NVN8; gene symbol GNL3L.
- Organism: Homo sapiens.
- Length: 582 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cancer and chronic obstructive pulmonary disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanine nucleotide-binding protein-like 3-like protein |
|---|---|
| UniProt accession | Q9NVN8 |
| Gene | GNL3L |
| Organism | Homo sapiens |
| Length | 582 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.13
- cancer · score 0.08
- chronic obstructive pulmonary disease · score 0.07
- esophageal squamous cell carcinoma · score 0.07
- neoplasm · score 0.04
- glioblastoma multiforme · score 0.03
- acute myeloid leukemia · score 0.02
- osteosarcoma · score 0.01
- testicular carcinoma · score 0.01
- bladder transitional cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVN8-F1 | alphafold | PREDICTED | 72.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVN8.
Amino-acid sequence (582 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GNL3L?
The strongest Open Targets associations for GNL3L are neurodegenerative disease, cancer, chronic obstructive pulmonary disease, esophageal squamous cell carcinoma and neoplasm.
How long is the GNL3L protein?
The Homo sapiens GNL3L protein (UniProt Q9NVN8) is 582 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.