ATP-dependent RNA helicase DDX18 (DDX18)
Homo sapiens — UniProt Q9NVP1
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent RNA helicase DDX18 (DDX18) is a protein from Homo sapiens identified by UniProt accession Q9NVP1, 670 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9NVP1; gene symbol DDX18.
- Organism: Homo sapiens.
- Length: 670 amino acids.
- Top disease associations (Open Targets): cognitive function measurement, low density lipoprotein cholesterol measurement and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent RNA helicase DDX18 |
|---|---|
| UniProt accession | Q9NVP1 |
| Gene | DDX18 |
| Organism | Homo sapiens |
| Length | 670 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- cognitive function measurement · score 0.36
- low density lipoprotein cholesterol measurement · score 0.34
- self reported educational attainment · score 0.31
- intelligence · score 0.31
- physical activity · score 0.29
- lymphocyte count · score 0.27
- total cholesterol measurement · score 0.16
- appendicular lean mass · score 0.10
- apolipoprotein B measurement · score 0.10
- heel bone mineral density · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVP1-F1 | alphafold | PREDICTED | 72.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVP1.
Amino-acid sequence (670 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX18?
The strongest Open Targets associations for DDX18 are cognitive function measurement, low density lipoprotein cholesterol measurement, self reported educational attainment, intelligence and physical activity.
How long is the DDX18 protein?
The Homo sapiens DDX18 protein (UniProt Q9NVP1) is 670 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVP1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVP1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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