Double zinc ribbon and ankyrin repeat-containing protein 1 (DZANK1)
Homo sapiens — UniProt Q9NVP4
Data last refreshed: (UniProt release unknown)
Key facts
Double zinc ribbon and ankyrin repeat-containing protein 1 (DZANK1) is a protein from Homo sapiens identified by UniProt accession Q9NVP4, 752 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9NVP4; gene symbol DZANK1.
- Organism: Homo sapiens.
- Length: 752 amino acids.
- Top disease associations (Open Targets): body mass index, neurofibrillary tangles measurement and age at menarche.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Double zinc ribbon and ankyrin repeat-containing protein 1 |
|---|---|
| UniProt accession | Q9NVP4 |
| Gene | DZANK1 |
| Organism | Homo sapiens |
| Length | 752 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- body mass index · score 0.31
- neurofibrillary tangles measurement · score 0.31
- age at menarche · score 0.30
- neurodegenerative disease · score 0.14
- hemoglobin measurement · score 0.13
- hematocrit · score 0.12
- genetic disorder · score 0.12
- attention deficit hyperactivity disorder · score 0.05
- schizophrenia 15 · score 0.04
- autoimmune thrombocytopenic purpura · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVP4-F1 | alphafold | PREDICTED | 64.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVP4.
Amino-acid sequence (752 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DZANK1?
The strongest Open Targets associations for DZANK1 are body mass index, neurofibrillary tangles measurement, age at menarche, neurodegenerative disease and hemoglobin measurement.
How long is the DZANK1 protein?
The Homo sapiens DZANK1 protein (UniProt Q9NVP4) is 752 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVP4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVP4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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