Pyridoxine-5'-phosphate oxidase (PNPO)
Homo sapiens — UniProt Q9NVS9
Data last refreshed: (UniProt release unknown)
Key facts
Pyridoxine-5'-phosphate oxidase (PNPO) is a protein from Homo sapiens identified by UniProt accession Q9NVS9, 261 residues long. MolForge cross-references it against 1 known binders and 112 disease associations.
- UniProt accession: Q9NVS9; gene symbol PNPO.
- Organism: Homo sapiens.
- Length: 261 amino acids.
- Top disease associations (Open Targets): pyridoxal phosphate-responsive seizures, genetic disorder and Seizure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pyridoxine-5'-phosphate oxidase |
|---|---|
| UniProt accession | Q9NVS9 |
| Gene | PNPO |
| Organism | Homo sapiens |
| Length | 261 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- pyridoxal phosphate-responsive seizures · score 0.81
- genetic disorder · score 0.48
- Seizure · score 0.36
- neuronopathy, distal hereditary motor, type 5A · score 0.34
- IMAGe syndrome · score 0.33
- fetal growth restriction · score 0.33
- Growth delay · score 0.33
- glutaryl-CoA dehydrogenase deficiency · score 0.27
- FEV/FVC ratio · score 0.26
- Global developmental delay · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVS9-F1 | alphafold | PREDICTED | 88.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVS9.
Amino-acid sequence (261 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PNPO?
The strongest Open Targets associations for PNPO are pyridoxal phosphate-responsive seizures, genetic disorder, Seizure, neuronopathy, distal hereditary motor, type 5A and IMAGe syndrome.
How long is the PNPO protein?
The Homo sapiens PNPO protein (UniProt Q9NVS9) is 261 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVS9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVS9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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