DNA-directed RNA polymerase III subunit RPC5 (POLR3E)
Homo sapiens — UniProt Q9NVU0
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) is a protein from Homo sapiens identified by UniProt accession Q9NVU0, 708 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9NVU0; gene symbol POLR3E.
- Organism: Homo sapiens.
- Length: 708 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and body weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC5 |
|---|---|
| UniProt accession | Q9NVU0 |
| Gene | POLR3E |
| Organism | Homo sapiens |
| Length | 708 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- body height · score 0.29
- body weight · score 0.23
- urate measurement · score 0.20
- bone density · score 0.20
- bacteriemia · score 0.01
- Obesity · score 0.01
- neoplasm · score 0.00
- cancer · score 0.00
- juvenile dermatomyositis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVU0-F1 | alphafold | PREDICTED | 78.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVU0.
Amino-acid sequence (708 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR3E?
The strongest Open Targets associations for POLR3E are neurodegenerative disease, body height, body weight, urate measurement and bone density.
How long is the POLR3E protein?
The Homo sapiens POLR3E protein (UniProt Q9NVU0) is 708 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVU0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVU0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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