Trimeric intracellular cation channel type B (TMEM38B)
Homo sapiens — UniProt Q9NVV0
Data last refreshed: (UniProt release unknown)
Key facts
Trimeric intracellular cation channel type B (TMEM38B) is a protein from Homo sapiens identified by UniProt accession Q9NVV0, 291 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q9NVV0; gene symbol TMEM38B.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): osteogenesis imperfecta, osteogenesis imperfecta type 4 and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trimeric intracellular cation channel type B |
|---|---|
| UniProt accession | Q9NVV0 |
| Gene | TMEM38B |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta · score 0.65
- osteogenesis imperfecta type 4 · score 0.37
- schizophrenia · score 0.29
- autism spectrum disorder · score 0.29
- apolipoprotein A 1 measurement · score 0.24
- alcohol consumption measurement · score 0.21
- age at menarche · score 0.20
- genetic disorder · score 0.19
- neurofibrillary tangles measurement · score 0.19
- mathematical ability · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVV0-F1 | alphafold | PREDICTED | 79.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVV0.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM38B?
The strongest Open Targets associations for TMEM38B are osteogenesis imperfecta, osteogenesis imperfecta type 4, schizophrenia, autism spectrum disorder and apolipoprotein A 1 measurement.
How long is the TMEM38B protein?
The Homo sapiens TMEM38B protein (UniProt Q9NVV0) is 291 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVV0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVV0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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