Poly(A) RNA polymerase, mitochondrial (MTPAP)
Homo sapiens — UniProt Q9NVV4
Data last refreshed: (UniProt release unknown)
Key facts
Poly(A) RNA polymerase, mitochondrial (MTPAP) is a protein from Homo sapiens identified by UniProt accession Q9NVV4, 582 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9NVV4; gene symbol MTPAP.
- Organism: Homo sapiens.
- Length: 582 amino acids.
- Top disease associations (Open Targets): spastic ataxia 4, Autosomal recessive spastic ataxia - optic atrophy - dysarthria and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Poly(A) RNA polymerase, mitochondrial |
|---|---|
| UniProt accession | Q9NVV4 |
| Gene | MTPAP |
| Organism | Homo sapiens |
| Length | 582 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- spastic ataxia 4 · score 0.58
- Autosomal recessive spastic ataxia - optic atrophy - dysarthria · score 0.57
- neurodegenerative disease · score 0.52
- autosomal recessive spastic ataxia · score 0.40
- mitochondrial disease · score 0.37
- spastic ataxia · score 0.27
- genetic disorder · score 0.19
- lysosomal storage disease · score 0.16
- platelet count · score 0.15
- lymphocyte count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVV4-F1 | alphafold | PREDICTED | 82.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVV4.
Amino-acid sequence (582 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTPAP?
The strongest Open Targets associations for MTPAP are spastic ataxia 4, Autosomal recessive spastic ataxia - optic atrophy - dysarthria, neurodegenerative disease, autosomal recessive spastic ataxia and mitochondrial disease.
How long is the MTPAP protein?
The Homo sapiens MTPAP protein (UniProt Q9NVV4) is 582 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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