THAP domain-containing protein 1 (THAP1)
Homo sapiens — UniProt Q9NVV9
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 1 (THAP1) is a protein from Homo sapiens identified by UniProt accession Q9NVV9, 213 residues long. MolForge cross-references it against 4 known binders and 115 disease associations.
- UniProt accession: Q9NVV9; gene symbol THAP1.
- Organism: Homo sapiens.
- Length: 213 amino acids.
- Top disease associations (Open Targets): Primary dystonia, DYT6 type, torsion dystonia 6 and Dystonia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 1 |
|---|---|
| UniProt accession | Q9NVV9 |
| Gene | THAP1 |
| Organism | Homo sapiens |
| Length | 213 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- Primary dystonia, DYT6 type · score 0.81
- torsion dystonia 6 · score 0.77
- Dystonia · score 0.54
- neurodegenerative disease · score 0.53
- dystonic disorder · score 0.31
- genetic disorder · score 0.18
- monocyte percentage of leukocytes · score 0.14
- waist circumference · score 0.08
- body height · score 0.08
- Fuchs endothelial corneal dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVV9-F1 | alphafold | PREDICTED | 70.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVV9.
Amino-acid sequence (213 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP1?
The strongest Open Targets associations for THAP1 are Primary dystonia, DYT6 type, torsion dystonia 6, Dystonia, neurodegenerative disease and dystonic disorder.
How long is the THAP1 protein?
The Homo sapiens THAP1 protein (UniProt Q9NVV9) is 213 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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