E3 ubiquitin-protein ligase RLIM (RLIM)
Homo sapiens — UniProt Q9NVW2
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RLIM (RLIM) is a protein from Homo sapiens identified by UniProt accession Q9NVW2, 624 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.
- UniProt accession: Q9NVW2; gene symbol RLIM.
- Organism: Homo sapiens.
- Length: 624 amino acids.
- Top disease associations (Open Targets): X-linked non-syndromic intellectual disability, Intellectual disability and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RLIM |
|---|---|
| UniProt accession | Q9NVW2 |
| Gene | RLIM |
| Organism | Homo sapiens |
| Length | 624 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (111)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.67
- Intellectual disability · score 0.61
- neurodegenerative disease · score 0.43
- non-syndromic X-linked intellectual disability · score 0.40
- complex neurodevelopmental disorder · score 0.37
- Global developmental delay · score 0.34
- genetic disorder · score 0.33
- hemoglobin A1 measurement · score 0.21
- clear cell renal carcinoma · score 0.18
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVW2-F1 | alphafold | PREDICTED | 49.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVW2.
Amino-acid sequence (624 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RLIM?
The strongest Open Targets associations for RLIM are X-linked non-syndromic intellectual disability, Intellectual disability, neurodegenerative disease, non-syndromic X-linked intellectual disability and complex neurodevelopmental disorder.
How long is the RLIM protein?
The Homo sapiens RLIM protein (UniProt Q9NVW2) is 624 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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