Notchless protein homolog 1 (NLE1)
Homo sapiens — UniProt Q9NVX2
Data last refreshed: (UniProt release unknown)
Key facts
Notchless protein homolog 1 (NLE1) is a protein from Homo sapiens identified by UniProt accession Q9NVX2, 485 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9NVX2; gene symbol NLE1.
- Organism: Homo sapiens.
- Length: 485 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Notchless protein homolog 1 |
|---|---|
| UniProt accession | Q9NVX2 |
| Gene | NLE1 |
| Organism | Homo sapiens |
| Length | 485 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- lysosomal storage disease · score 0.20
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.07
- melanoma · score 0.04
- blood protein measurement · score 0.02
- diffuse large B-cell lymphoma · score 0.02
- lung carcinoma · score 0.02
- cancer · score 0.02
- metastatic colorectal cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVX2-F1 | alphafold | PREDICTED | 93.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVX2.
Amino-acid sequence (485 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NLE1?
The strongest Open Targets associations for NLE1 are neurodegenerative disease, lysosomal storage disease, neoplasm, non-small cell lung carcinoma and melanoma.
How long is the NLE1 protein?
The Homo sapiens NLE1 protein (UniProt Q9NVX2) is 485 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVX2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVX2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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