Adaptin ear-binding coat-associated protein 2 (NECAP2)
Homo sapiens — UniProt Q9NVZ3
Data last refreshed: (UniProt release unknown)
Key facts
Adaptin ear-binding coat-associated protein 2 (NECAP2) is a protein from Homo sapiens identified by UniProt accession Q9NVZ3, 263 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9NVZ3; gene symbol NECAP2.
- Organism: Homo sapiens.
- Length: 263 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adaptin ear-binding coat-associated protein 2 |
|---|---|
| UniProt accession | Q9NVZ3 |
| Gene | NECAP2 |
| Organism | Homo sapiens |
| Length | 263 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- lysosomal storage disease · score 0.30
- Parkinson disease · score 0.30
- multiple sclerosis · score 0.30
- Alzheimer disease · score 0.30
- glioblastoma multiforme · score 0.23
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- body mass index · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NVZ3-F1 | alphafold | PREDICTED | 69.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NVZ3.
Amino-acid sequence (263 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NECAP2?
The strongest Open Targets associations for NECAP2 are neurodegenerative disease, lysosomal storage disease, Parkinson disease, multiple sclerosis and Alzheimer disease.
How long is the NECAP2 protein?
The Homo sapiens NECAP2 protein (UniProt Q9NVZ3) is 263 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NVZ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NVZ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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