Pleckstrin homology domain-containing family J member 1 (PLEKHJ1)
Homo sapiens — UniProt Q9NW61
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family J member 1 (PLEKHJ1) is a protein from Homo sapiens identified by UniProt accession Q9NW61, 149 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9NW61; gene symbol PLEKHJ1.
- Organism: Homo sapiens.
- Length: 149 amino acids.
- Top disease associations (Open Targets): body mass index, pulse pressure measurement and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family J member 1 |
|---|---|
| UniProt accession | Q9NW61 |
| Gene | PLEKHJ1 |
| Organism | Homo sapiens |
| Length | 149 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- body mass index · score 0.14
- pulse pressure measurement · score 0.11
- appendicular lean mass · score 0.08
- systolic blood pressure · score 0.06
- body fat percentage · score 0.05
- migraine disorder · score 0.05
- platelet count · score 0.05
- platelet crit · score 0.04
- atrial fibrillation · score 0.04
- atrial flutter · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NW61-F1 | alphafold | PREDICTED | 90.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NW61.
Amino-acid sequence (149 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHJ1?
The strongest Open Targets associations for PLEKHJ1 are body mass index, pulse pressure measurement, appendicular lean mass, systolic blood pressure and body fat percentage.
How long is the PLEKHJ1 protein?
The Homo sapiens PLEKHJ1 protein (UniProt Q9NW61) is 149 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NW61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NW61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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