RNA binding protein fox-1 homolog 1 (RBFOX1)
Homo sapiens — UniProt Q9NWB1
Data last refreshed: (UniProt release unknown)
Key facts
RNA binding protein fox-1 homolog 1 (RBFOX1) is a protein from Homo sapiens identified by UniProt accession Q9NWB1, 397 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.
- UniProt accession: Q9NWB1; gene symbol RBFOX1.
- Organism: Homo sapiens.
- Length: 397 amino acids.
- Top disease associations (Open Targets): Rolandic epilepsy, childhood epilepsy with centrotemporal spikes and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA binding protein fox-1 homolog 1 |
|---|---|
| UniProt accession | Q9NWB1 |
| Gene | RBFOX1 |
| Organism | Homo sapiens |
| Length | 397 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (251)
Diseases linked to this target (Open Targets).
- Rolandic epilepsy · score 0.48
- childhood epilepsy with centrotemporal spikes · score 0.47
- genetic disorder · score 0.45
- refractive error · score 0.44
- self reported educational attainment · score 0.43
- refractive error measurement · score 0.43
- Myopia · score 0.43
- neuroticism measurement · score 0.42
- unipolar depression · score 0.41
- depressive symptom measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWB1-F1 | alphafold | PREDICTED | 55.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWB1.
Amino-acid sequence (397 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RBFOX1?
The strongest Open Targets associations for RBFOX1 are Rolandic epilepsy, childhood epilepsy with centrotemporal spikes, genetic disorder, refractive error and self reported educational attainment.
How long is the RBFOX1 protein?
The Homo sapiens RBFOX1 protein (UniProt Q9NWB1) is 397 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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