Intraflagellar transport protein 57 homolog (IFT57)
Homo sapiens — UniProt Q9NWB7
Data last refreshed: (UniProt release unknown)
Key facts
Intraflagellar transport protein 57 homolog (IFT57) is a protein from Homo sapiens identified by UniProt accession Q9NWB7, 429 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q9NWB7; gene symbol IFT57.
- Organism: Homo sapiens.
- Length: 429 amino acids.
- Top disease associations (Open Targets): orofaciodigital syndrome, neurodegenerative disease and social interaction measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Intraflagellar transport protein 57 homolog |
|---|---|
| UniProt accession | Q9NWB7 |
| Gene | IFT57 |
| Organism | Homo sapiens |
| Length | 429 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- orofaciodigital syndrome · score 0.43
- neurodegenerative disease · score 0.26
- social interaction measurement · score 0.21
- body height · score 0.19
- body mass index · score 0.16
- smoking cessation · score 0.16
- insomnia measurement · score 0.15
- age at first sexual intercourse measurement · score 0.14
- cognitive function measurement · score 0.11
- mathematical ability · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWB7-F1 | alphafold | PREDICTED | 76.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWB7.
Amino-acid sequence (429 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFT57?
The strongest Open Targets associations for IFT57 are orofaciodigital syndrome, neurodegenerative disease, social interaction measurement, body height and body mass index.
How long is the IFT57 protein?
The Homo sapiens IFT57 protein (UniProt Q9NWB7) is 429 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWB7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWB7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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