E3 ubiquitin-protein ligase RNF216 (RNF216)
Homo sapiens — UniProt Q9NWF9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF216 (RNF216) is a protein from Homo sapiens identified by UniProt accession Q9NWF9, 866 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.
- UniProt accession: Q9NWF9; gene symbol RNF216.
- Organism: Homo sapiens.
- Length: 866 amino acids.
- Top disease associations (Open Targets): cerebellar ataxia-hypogonadism syndrome, Cerebellar ataxia - hypogonadism and hypogonadotropic hypogonadism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF216 |
|---|---|
| UniProt accession | Q9NWF9 |
| Gene | RNF216 |
| Organism | Homo sapiens |
| Length | 866 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (166)
Diseases linked to this target (Open Targets).
- cerebellar ataxia-hypogonadism syndrome · score 0.77
- Cerebellar ataxia - hypogonadism · score 0.75
- hypogonadotropic hypogonadism · score 0.27
- mathematical ability · score 0.26
- leukodystrophy · score 0.26
- self reported educational attainment · score 0.26
- monocyte count · score 0.24
- cognitive function measurement · score 0.22
- body mass index · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWF9-F1 | alphafold | PREDICTED | 62.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWF9.
Amino-acid sequence (866 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF216?
The strongest Open Targets associations for RNF216 are cerebellar ataxia-hypogonadism syndrome, Cerebellar ataxia - hypogonadism, hypogonadotropic hypogonadism, mathematical ability and leukodystrophy.
How long is the RNF216 protein?
The Homo sapiens RNF216 protein (UniProt Q9NWF9) is 866 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWF9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWF9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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