Calcium uniporter regulatory subunit MCUb…

About Calcium uniporter regulatory subunit MCUb, mitochondrial

Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB) is a protein from Homo sapiens identified by UniProt accession Q9NWR8, 336 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Calcium uniporter regulatory subunit MCUb, mitochondrial
UniProt accession	Q9NWR8
Gene	MCUB
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

age-related macular degeneration · score 0.26
risk-taking behaviour · score 0.22
Myocardial Ischemia · score 0.09
testosterone measurement · score 0.04
glioblastoma multiforme · score 0.03
blood protein measurement · score 0.02
neoplasm · score 0.02
mean corpuscular volume · score 0.02
triglyceride measurement · score 0.02
clear cell renal carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NWR8-F1	alphafold	PREDICTED	76.21	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWR8.

Amino-acid sequence (336 residues)

MLQRGLWPWR TRLLPTPGTW RPARPWPLPP PPQVLRVKLC GNVKYYQSHH YSTVVPPDEI TVIYRHGLPL VTLTLPSRKE RCQFVVKPML STVGSFLQDL QNEDKGIKTA AIFTADGNMI SASTLMDILL MNDFKLVINK IAYDVQCPKR EKPSNEHTAE MEHMKSLVHR LFTILHLEES QKKREHHLLE KIDHLKEQLQ PLEQVKAGIE AHSEAKTSGL LWAGLALLSI QGGALAWLTW WVYSWDIMEP VTYFITFANS MVFFAYFIVT RQDYTYSAVK SRQFLQFFHK KSKQQHFDVQ QYNKLKEDLA KAKESLKQAR HSLCLQMQVE ELNEKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB)