Large ribosomal subunit protein uL22m (MRPL22)
Homo sapiens — UniProt Q9NWU5
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein uL22m (MRPL22) is a protein from Homo sapiens identified by UniProt accession Q9NWU5, 206 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9NWU5; gene symbol MRPL22.
- Organism: Homo sapiens.
- Length: 206 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein uL22m |
|---|---|
| UniProt accession | Q9NWU5 |
| Gene | MRPL22 |
| Organism | Homo sapiens |
| Length | 206 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- mean corpuscular volume · score 0.34
- mean corpuscular hemoglobin concentration · score 0.28
- erythrocyte count · score 0.27
- mean corpuscular hemoglobin · score 0.18
- red blood cell density measurement · score 0.16
- bowel opening frequency · score 0.11
- PHF-tau measurement · score 0.11
- adolescent idiopathic scoliosis · score 0.08
- reticulocyte measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWU5-F1 | alphafold | PREDICTED | 85.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWU5.
Amino-acid sequence (206 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL22?
The strongest Open Targets associations for MRPL22 are neurodegenerative disease, mean corpuscular volume, mean corpuscular hemoglobin concentration, erythrocyte count and mean corpuscular hemoglobin.
How long is the MRPL22 protein?
The Homo sapiens MRPL22 protein (UniProt Q9NWU5) is 206 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWU5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWU5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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