Probable tRNA(His) guanylyltransferase (THG1L)
Homo sapiens — UniProt Q9NWX6
Data last refreshed: (UniProt release unknown)
Key facts
Probable tRNA(His) guanylyltransferase (THG1L) is a protein from Homo sapiens identified by UniProt accession Q9NWX6, 298 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9NWX6; gene symbol THG1L.
- Organism: Homo sapiens.
- Length: 298 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia, autosomal recessive 28, Red cell distribution width and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable tRNA(His) guanylyltransferase |
|---|---|
| UniProt accession | Q9NWX6 |
| Gene | THG1L |
| Organism | Homo sapiens |
| Length | 298 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia, autosomal recessive 28 · score 0.50
- Red cell distribution width · score 0.43
- Neurodevelopmental disorder · score 0.41
- mean reticulocyte volume · score 0.33
- mean corpuscular volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.30
- genetic disorder · score 0.19
- smoking status measurement · score 0.11
- Hallux valgus · score 0.08
- Lynch syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWX6-F1 | alphafold | PREDICTED | 89.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWX6.
Amino-acid sequence (298 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THG1L?
The strongest Open Targets associations for THG1L are spinocerebellar ataxia, autosomal recessive 28, Red cell distribution width, Neurodevelopmental disorder, mean reticulocyte volume and mean corpuscular volume.
How long is the THG1L protein?
The Homo sapiens THG1L protein (UniProt Q9NWX6) is 298 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWX6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWX6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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