Histone PARylation factor 1 (HPF1)
Homo sapiens — UniProt Q9NWY4
Data last refreshed: (UniProt release unknown)
Key facts
Histone PARylation factor 1 (HPF1) is a protein from Homo sapiens identified by UniProt accession Q9NWY4, 346 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9NWY4; gene symbol HPF1.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): schizophrenia, Blackfan-Diamond anemia and Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone PARylation factor 1 |
|---|---|
| UniProt accession | Q9NWY4 |
| Gene | HPF1 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.06
- Blackfan-Diamond anemia · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- hemoglobin D disease · score 0.04
- Heinz body anemia · score 0.04
- Congenital dyserythropoietic anemia type I · score 0.04
- IRIDA syndrome · score 0.04
- delta-beta-thalassemia · score 0.04
- overhydrated hereditary stomatocytosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWY4-F1 | alphafold | PREDICTED | 90.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWY4.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HPF1?
The strongest Open Targets associations for HPF1 are schizophrenia, Blackfan-Diamond anemia, Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16, alpha thalassemia-intellectual disability syndrome type 1 and hemoglobin D disease.
How long is the HPF1 protein?
The Homo sapiens HPF1 protein (UniProt Q9NWY4) is 346 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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