Interleukin-1 receptor-associated kinase 4 (IRAK4)
Homo sapiens — UniProt Q9NWZ3
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a protein from Homo sapiens identified by UniProt accession Q9NWZ3, 460 residues long. MolForge cross-references it against 12 known binders and 283 disease associations.
- UniProt accession: Q9NWZ3; gene symbol IRAK4.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Approved drugs acting on it (DrugCentral): Tepotinib.
- Top disease associations (Open Targets): Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency, immunodeficiency 67 and inborn error of immunity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-1 receptor-associated kinase 4 |
|---|---|
| UniProt accession | Q9NWZ3 |
| Gene | IRAK4 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (283)
Diseases linked to this target (Open Targets).
- Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.79
- immunodeficiency 67 · score 0.78
- inborn error of immunity · score 0.53
- neuroinflammatory disorder · score 0.37
- immunodeficiency 33 · score 0.34
- congenital dyserythropoietic anemia · score 0.30
- neurodegenerative disease · score 0.25
- lung adenocarcinoma · score 0.24
- chronic lymphocytic leukemia · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWZ3-F1 | alphafold | PREDICTED | 83.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWZ3.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target IRAK4?
DrugCentral lists 1 approved drug whose mechanism of action is IRAK4: Tepotinib.
Which diseases are associated with IRAK4?
The strongest Open Targets associations for IRAK4 are Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency, immunodeficiency 67, inborn error of immunity, neuroinflammatory disorder and immunodeficiency 33.
How long is the IRAK4 protein?
The Homo sapiens IRAK4 protein (UniProt Q9NWZ3) is 460 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWZ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWZ3 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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