Uridine-cytidine kinase-like 1 (UCKL1)
Homo sapiens — UniProt Q9NWZ5
Data last refreshed: (UniProt release unknown)
Key facts
Uridine-cytidine kinase-like 1 (UCKL1) is a protein from Homo sapiens identified by UniProt accession Q9NWZ5, 548 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q9NWZ5; gene symbol UCKL1.
- Organism: Homo sapiens.
- Length: 548 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuronal ceroid lipofuscinosis and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Uridine-cytidine kinase-like 1 |
|---|---|
| UniProt accession | Q9NWZ5 |
| Gene | UCKL1 |
| Organism | Homo sapiens |
| Length | 548 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- neuronal ceroid lipofuscinosis · score 0.12
- type 2 diabetes mellitus · score 0.12
- alkaline phosphatase measurement · score 0.12
- grip strength measurement · score 0.11
- mean platelet volume · score 0.10
- neoplasm · score 0.10
- urate measurement · score 0.07
- reticulocyte count · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWZ5-F1 | alphafold | PREDICTED | 80.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWZ5.
Amino-acid sequence (548 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UCKL1?
The strongest Open Targets associations for UCKL1 are neurodegenerative disease, neuronal ceroid lipofuscinosis, type 2 diabetes mellitus, alkaline phosphatase measurement and grip strength measurement.
How long is the UCKL1 protein?
The Homo sapiens UCKL1 protein (UniProt Q9NWZ5) is 548 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWZ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWZ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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