Constitutive coactivator of PPAR-gamma-like protein 2 (FAM120C)
Homo sapiens — UniProt Q9NX05
Data last refreshed: (UniProt release unknown)
Key facts
Constitutive coactivator of PPAR-gamma-like protein 2 (FAM120C) is a protein from Homo sapiens identified by UniProt accession Q9NX05, 1096 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9NX05; gene symbol FAM120C.
- Organism: Homo sapiens.
- Length: 1096 amino acids.
- Top disease associations (Open Targets): glycoprotein storage disease, hemoglobin H disease and dominant beta-thalassemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Constitutive coactivator of PPAR-gamma-like protein 2 |
|---|---|
| UniProt accession | Q9NX05 |
| Gene | FAM120C |
| Organism | Homo sapiens |
| Length | 1096 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- glycoprotein storage disease · score 0.04
- hemoglobin H disease · score 0.04
- dominant beta-thalassemia · score 0.04
- hemoglobin C-beta-thalassemia syndrome · score 0.04
- neuronal ceroid lipofuscinosis 1 · score 0.04
- kidney disease · score 0.04
- combined immunodeficiency due to OX40 deficiency · score 0.04
- Hyperlipoproteinemia type 1 · score 0.04
- erythroleukemia, familial, susceptibility to · score 0.03
- hereditary neutrophilia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX05-F1 | alphafold | PREDICTED | 68.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX05.
Amino-acid sequence (1096 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM120C?
The strongest Open Targets associations for FAM120C are glycoprotein storage disease, hemoglobin H disease, dominant beta-thalassemia, hemoglobin C-beta-thalassemia syndrome and neuronal ceroid lipofuscinosis 1.
How long is the FAM120C protein?
The Homo sapiens FAM120C protein (UniProt Q9NX05) is 1096 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX05 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX05 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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