NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (NDUFB11)
Homo sapiens — UniProt Q9NX14
Data last refreshed: (UniProt release unknown)
Key facts
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) is a protein from Homo sapiens identified by UniProt accession Q9NX14, 153 residues long. MolForge cross-references it against 0 known binders and 254 disease associations.
- UniProt accession: Q9NX14; gene symbol NDUFB11.
- Organism: Homo sapiens.
- Length: 153 amino acids.
- Top disease associations (Open Targets): Microphthalmia with linear skin defects syndrome, mitochondrial complex I deficiency and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial |
|---|---|
| UniProt accession | Q9NX14 |
| Gene | NDUFB11 |
| Organism | Homo sapiens |
| Length | 153 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (254)
Diseases linked to this target (Open Targets).
- Microphthalmia with linear skin defects syndrome · score 0.78
- mitochondrial complex I deficiency · score 0.62
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- obesity · score 0.57
- histiocytoid cardiomyopathy · score 0.57
- prediabetes syndrome · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX14-F1 | alphafold | PREDICTED | 77.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX14.
Amino-acid sequence (153 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NDUFB11?
The strongest Open Targets associations for NDUFB11 are Microphthalmia with linear skin defects syndrome, mitochondrial complex I deficiency, type 2 diabetes mellitus, diabetes mellitus and polycystic ovary syndrome.
How long is the NDUFB11 protein?
The Homo sapiens NDUFB11 protein (UniProt Q9NX14) is 153 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX14 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX14 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.