Succinate dehydrogenase assembly factor 2…

About Succinate dehydrogenase assembly factor 2, mitochondrial

Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) is a protein from Homo sapiens identified by UniProt accession Q9NX18, 166 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Succinate dehydrogenase assembly factor 2, mitochondrial
UniProt accession	Q9NX18
Gene	SDHAF2
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

Paraganglioma · score 0.70
hereditary pheochromocytoma-paraganglioma · score 0.70
hereditary neoplastic syndrome · score 0.55
Inherited cancer-predisposing syndrome · score 0.55
malignant endocrine neoplasm · score 0.37
neuroendocrine carcinoma · score 0.37
bile duct carcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
endocrine neoplasm · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NX18-F1	alphafold	PREDICTED	83.37	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX18.

Amino-acid sequence (166 residues)

MAVSTVFSTS SLMLALSRHS LLSPLLSVTS FRRFYRGDSP TDSQKDMIEI PLPPWQERTD ESIETKRARL LYESRKRGML ENCILLSLFA KEHLQHMTEK QLNLYDRLIN EPSNDWDIYY WATEAKPAPE IFENEVMALL RDFAKNKNKE QRLRAPDLEY LFEKPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2)