H/ACA ribonucleoprotein complex subunit 2 (NHP2)
Homo sapiens — UniProt Q9NX24
Data last refreshed: (UniProt release unknown)
Key facts
H/ACA ribonucleoprotein complex subunit 2 (NHP2) is a protein from Homo sapiens identified by UniProt accession Q9NX24, 153 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9NX24; gene symbol NHP2.
- Organism: Homo sapiens.
- Length: 153 amino acids.
- Top disease associations (Open Targets): dyskeratosis congenita, Hoyeraal-Hreidarsson syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | H/ACA ribonucleoprotein complex subunit 2 |
|---|---|
| UniProt accession | Q9NX24 |
| Gene | NHP2 |
| Organism | Homo sapiens |
| Length | 153 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita · score 0.77
- Hoyeraal-Hreidarsson syndrome · score 0.46
- neurodegenerative disease · score 0.19
- multiple sclerosis · score 0.19
- lysosomal storage disease · score 0.19
- Alzheimer disease · score 0.19
- Parkinson disease · score 0.19
- endometrial cancer · score 0.19
- hepatocellular carcinoma · score 0.06
- cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX24-F1 | alphafold | PREDICTED | 80.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX24.
Amino-acid sequence (153 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NHP2?
The strongest Open Targets associations for NHP2 are dyskeratosis congenita, Hoyeraal-Hreidarsson syndrome, neurodegenerative disease, multiple sclerosis and lysosomal storage disease.
How long is the NHP2 protein?
The Homo sapiens NHP2 protein (UniProt Q9NX24) is 153 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX24 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX24 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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