Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (SOHLH2)
Homo sapiens — UniProt Q9NX45
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (SOHLH2) is a protein from Homo sapiens identified by UniProt accession Q9NX45, 425 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.
- UniProt accession: Q9NX45; gene symbol SOHLH2.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, gastric adenocarcinoma and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 |
|---|---|
| UniProt accession | Q9NX45 |
| Gene | SOHLH2 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (162)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.20
- gastric adenocarcinoma · score 0.14
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure 25 · score 0.08
- spinocerebellar ataxia type 32 · score 0.07
- triple-negative breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX45-F1 | alphafold | PREDICTED | 57.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX45.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOHLH2?
The strongest Open Targets associations for SOHLH2 are primary ovarian insufficiency, gastric adenocarcinoma, azoospermia, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
How long is the SOHLH2 protein?
The Homo sapiens SOHLH2 protein (UniProt Q9NX45) is 425 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX45 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX45 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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