ADP-ribosylhydrolase ARH3 (ADPRS)
Homo sapiens — UniProt Q9NX46
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylhydrolase ARH3 (ADPRS) is a protein from Homo sapiens identified by UniProt accession Q9NX46, 363 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9NX46; gene symbol ADPRS.
- Organism: Homo sapiens.
- Length: 363 amino acids.
- Top disease associations (Open Targets): neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures, genetic disorder and Delayed speech and language development.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylhydrolase ARH3 |
|---|---|
| UniProt accession | Q9NX46 |
| Gene | ADPRS |
| Organism | Homo sapiens |
| Length | 363 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures · score 0.72
- genetic disorder · score 0.19
- Delayed speech and language development · score 0.11
- Abdominal distention · score 0.11
- Progressive sensorineural hearing impairment · score 0.11
- Loss of consciousness · score 0.11
- Axial hypotonia · score 0.11
- Sensorineural hearing impairment · score 0.11
- refractive error measurement · score 0.09
- intraocular pressure measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX46-F1 | alphafold | PREDICTED | 94.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX46.
Amino-acid sequence (363 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADPRS?
The strongest Open Targets associations for ADPRS are neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures, genetic disorder, Delayed speech and language development, Abdominal distention and Progressive sensorineural hearing impairment.
How long is the ADPRS protein?
The Homo sapiens ADPRS protein (UniProt Q9NX46) is 363 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX46 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX46 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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