E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)
Homo sapiens — UniProt Q9NX47
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) is a protein from Homo sapiens identified by UniProt accession Q9NX47, 278 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9NX47; gene symbol MARCHF5.
- Organism: Homo sapiens.
- Length: 278 amino acids.
- Top disease associations (Open Targets): waist-hip ratio, type 1 diabetes mellitus and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF5 |
|---|---|
| UniProt accession | Q9NX47 |
| Gene | MARCHF5 |
| Organism | Homo sapiens |
| Length | 278 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- waist-hip ratio · score 0.33
- type 1 diabetes mellitus · score 0.22
- monocyte count · score 0.22
- mean platelet volume · score 0.19
- type 2 diabetes mellitus · score 0.18
- chronotype measurement · score 0.17
- monocyte percentage of leukocytes · score 0.16
- sex hormone-binding globulin measurement · score 0.15
- gastric carcinoma · score 0.15
- appendicular lean mass · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX47-F1 | alphafold | PREDICTED | 85.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX47.
Amino-acid sequence (278 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARCHF5?
The strongest Open Targets associations for MARCHF5 are waist-hip ratio, type 1 diabetes mellitus, monocyte count, mean platelet volume and type 2 diabetes mellitus.
How long is the MARCHF5 protein?
The Homo sapiens MARCHF5 protein (UniProt Q9NX47) is 278 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX47 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX47 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.