Rhomboid-related protein 2 (RHBDL2)
Homo sapiens — UniProt Q9NX52
Data last refreshed: (UniProt release unknown)
Key facts
Rhomboid-related protein 2 (RHBDL2) is a protein from Homo sapiens identified by UniProt accession Q9NX52, 303 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9NX52; gene symbol RHBDL2.
- Organism: Homo sapiens.
- Length: 303 amino acids.
- Top disease associations (Open Targets): Urinary incontinence, age at menopause and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rhomboid-related protein 2 |
|---|---|
| UniProt accession | Q9NX52 |
| Gene | RHBDL2 |
| Organism | Homo sapiens |
| Length | 303 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- Urinary incontinence · score 0.26
- age at menopause · score 0.22
- neurodegenerative disease · score 0.21
- triglyceride measurement · score 0.20
- neutrophil count · score 0.19
- leukocyte count · score 0.19
- hematocrit · score 0.16
- sex hormone-binding globulin measurement · score 0.16
- Kunitz-type protease inhibitor 1 measurement · score 0.15
- protein measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX52-F1 | alphafold | PREDICTED | 85.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX52.
Amino-acid sequence (303 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHBDL2?
The strongest Open Targets associations for RHBDL2 are Urinary incontinence, age at menopause, neurodegenerative disease, triglyceride measurement and neutrophil count.
How long is the RHBDL2 protein?
The Homo sapiens RHBDL2 protein (UniProt Q9NX52) is 303 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX52 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX52 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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