Rhomboid-related protein 2 (RHBDL2)

About Rhomboid-related protein 2

Rhomboid-related protein 2 (RHBDL2) is a protein from Homo sapiens identified by UniProt accession Q9NX52, 303 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Rhomboid-related protein 2
UniProt accession	Q9NX52
Gene	RHBDL2
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

Urinary incontinence · score 0.26
age at menopause · score 0.22
neurodegenerative disease · score 0.21
triglyceride measurement · score 0.20
neutrophil count · score 0.19
leukocyte count · score 0.19
hematocrit · score 0.16
sex hormone-binding globulin measurement · score 0.16
Kunitz-type protease inhibitor 1 measurement · score 0.15
protein measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NX52-F1	alphafold	PREDICTED	85.76	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX52.

Amino-acid sequence (303 residues)

MAAVHDLEME SMNLNMGREM KEELEEEEKM REDGGGKDRA KSKKVHRIVS KWMLPEKSRG TYLERANCFP PPVFIISISL AELAVFIYYA VWKPQKQWIT LDTGILESPF IYSPEKREEA WRFISYMLVH AGVQHILGNL CMQLVLGIPL EMVHKGLRVG LVYLAGVIAG SLASSIFDPL RYLVGASGGV YALMGGYFMN VLVNFQEMIP AFGIFRLLII ILIIVLDMGF ALYRRFFVPE DGSPVSFAAH IAGGFAGMSI GYTVFSCFDK ALLKDPRFWI AIAAYLACVL FAVFFNIFLS PAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards