Huntingtin-interacting protein K (HYPK)
Homo sapiens — UniProt Q9NX55
Data last refreshed: (UniProt release unknown)
Key facts
Huntingtin-interacting protein K (HYPK) is a protein from Homo sapiens identified by UniProt accession Q9NX55, 121 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q9NX55; gene symbol HYPK.
- Organism: Homo sapiens.
- Length: 121 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hemoglobin A1 measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Huntingtin-interacting protein K |
|---|---|
| UniProt accession | Q9NX55 |
| Gene | HYPK |
| Organism | Homo sapiens |
| Length | 121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- hemoglobin A1 measurement · score 0.06
- type 2 diabetes mellitus · score 0.04
- blood protein measurement · score 0.04
- susceptibility to urinary tract infection measurement · score 0.03
- Huntington disease · score 0.03
- diastolic blood pressure · score 0.02
- squamous cell carcinoma · score 0.01
- acute myeloid leukemia · score 0.00
- attention deficit hyperactivity disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX55-F1 | alphafold | PREDICTED | 70.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX55.
Amino-acid sequence (121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HYPK?
The strongest Open Targets associations for HYPK are neurodegenerative disease, hemoglobin A1 measurement, type 2 diabetes mellitus, blood protein measurement and susceptibility to urinary tract infection measurement.
How long is the HYPK protein?
The Homo sapiens HYPK protein (UniProt Q9NX55) is 121 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX55 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX55 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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