Ras-related protein Rab-20 (RAB20)
Homo sapiens — UniProt Q9NX57
Data last refreshed: (UniProt release unknown)
Key facts
Ras-related protein Rab-20 (RAB20) is a protein from Homo sapiens identified by UniProt accession Q9NX57, 234 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q9NX57; gene symbol RAB20.
- Organism: Homo sapiens.
- Length: 234 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and hair colour measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ras-related protein Rab-20 |
|---|---|
| UniProt accession | Q9NX57 |
| Gene | RAB20 |
| Organism | Homo sapiens |
| Length | 234 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- Parkinson disease · score 0.34
- hair colour measurement · score 0.33
- Alzheimer disease · score 0.33
- multiple sclerosis · score 0.33
- lysosomal storage disease · score 0.33
- hypothyroidism · score 0.31
- alkaline phosphatase measurement · score 0.18
- lymphocyte count · score 0.17
- otosclerosis · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX57-F1 | alphafold | PREDICTED | 86.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX57.
Amino-acid sequence (234 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RAB20?
The strongest Open Targets associations for RAB20 are neurodegenerative disease, Parkinson disease, hair colour measurement, Alzheimer disease and multiple sclerosis.
How long is the RAB20 protein?
The Homo sapiens RAB20 protein (UniProt Q9NX57) is 234 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX57 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX57 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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