Cell growth-regulating nucleolar protein (LYAR)
Homo sapiens — UniProt Q9NX58
Data last refreshed: (UniProt release unknown)
Key facts
Cell growth-regulating nucleolar protein (LYAR) is a protein from Homo sapiens identified by UniProt accession Q9NX58, 379 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q9NX58; gene symbol LYAR.
- Organism: Homo sapiens.
- Length: 379 amino acids.
- Top disease associations (Open Targets): neoplasm, MODY and physical activity measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cell growth-regulating nucleolar protein |
|---|---|
| UniProt accession | Q9NX58 |
| Gene | LYAR |
| Organism | Homo sapiens |
| Length | 379 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.08
- MODY · score 0.08
- physical activity measurement · score 0.06
- diabetes mellitus, transient neonatal, 2 · score 0.05
- cancer · score 0.05
- hepatocellular carcinoma · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.05
- permanent neonatal diabetes mellitus 1 · score 0.04
- hyperlipoproteinemia type V · score 0.04
- Hyperlipoproteinemia type 5 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX58-F1 | alphafold | PREDICTED | 70.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX58.
Amino-acid sequence (379 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LYAR?
The strongest Open Targets associations for LYAR are neoplasm, MODY, physical activity measurement, diabetes mellitus, transient neonatal, 2 and cancer.
How long is the LYAR protein?
The Homo sapiens LYAR protein (UniProt Q9NX58) is 379 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX58 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX58 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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