tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2)
Homo sapiens — UniProt Q9NX74
Data last refreshed: (UniProt release unknown)
Key facts
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2) is a protein from Homo sapiens identified by UniProt accession Q9NX74, 493 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9NX74; gene symbol DUS2.
- Organism: Homo sapiens.
- Length: 493 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like |
|---|---|
| UniProt accession | Q9NX74 |
| Gene | DUS2 |
| Organism | Homo sapiens |
| Length | 493 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- lysosomal storage disease · score 0.26
- high density lipoprotein cholesterol measurement · score 0.24
- alcohol consumption measurement · score 0.21
- alcohol drinking · score 0.20
- uric acid measurement · score 0.19
- urate measurement · score 0.17
- alkaline phosphatase measurement · score 0.15
- lipoprotein A measurement · score 0.14
- appendicular lean mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX74-F1 | alphafold | PREDICTED | 87.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX74.
Amino-acid sequence (493 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DUS2?
The strongest Open Targets associations for DUS2 are neurodegenerative disease, lysosomal storage disease, high density lipoprotein cholesterol measurement, alcohol consumption measurement and alcohol drinking.
How long is the DUS2 protein?
The Homo sapiens DUS2 protein (UniProt Q9NX74) is 493 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX74 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX74 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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