Protein O-mannosyl-transferase TMEM260 (TMEM260)
Homo sapiens — UniProt Q9NX78
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannosyl-transferase TMEM260 (TMEM260) is a protein from Homo sapiens identified by UniProt accession Q9NX78, 707 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9NX78; gene symbol TMEM260.
- Organism: Homo sapiens.
- Length: 707 amino acids.
- Top disease associations (Open Targets): Ulbright-Hodes syndrome, hip bone size and Type I truncus arteriosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannosyl-transferase TMEM260 |
|---|---|
| UniProt accession | Q9NX78 |
| Gene | TMEM260 |
| Organism | Homo sapiens |
| Length | 707 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- Ulbright-Hodes syndrome · score 0.67
- hip bone size · score 0.42
- Type I truncus arteriosus · score 0.34
- hip bone mineral density · score 0.33
- DNA methylation · score 0.32
- genetic disorder · score 0.19
- metabolite measurement · score 0.07
- exercise-induced hyperinsulinism · score 0.03
- congenital heart disease · score 0.02
- bacteriemia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NX78-F1 | alphafold | PREDICTED | 92.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NX78.
Amino-acid sequence (707 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM260?
The strongest Open Targets associations for TMEM260 are Ulbright-Hodes syndrome, hip bone size, Type I truncus arteriosus, hip bone mineral density and DNA methylation.
How long is the TMEM260 protein?
The Homo sapiens TMEM260 protein (UniProt Q9NX78) is 707 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NX78 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NX78 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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