NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
Homo sapiens — UniProt Q9NXA8
Data last refreshed: (UniProt release unknown)
Key facts
NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5) is a protein from Homo sapiens identified by UniProt accession Q9NXA8, 310 residues long. MolForge cross-references it against 7 known binders and 181 disease associations.
- UniProt accession: Q9NXA8; gene symbol SIRT5.
- Organism: Homo sapiens.
- Length: 310 amino acids.
- Top disease associations (Open Targets): lymphocyte count, platelet count and lymphocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
|---|---|
| UniProt accession | Q9NXA8 |
| Gene | SIRT5 |
| Organism | Homo sapiens |
| Length | 310 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.29
- platelet count · score 0.25
- lymphocyte percentage of leukocytes · score 0.23
- neutrophil percentage of leukocytes · score 0.19
- aspartate aminotransferase measurement · score 0.11
- hepatocellular carcinoma · score 0.10
- nonpapillary renal cell carcinoma · score 0.09
- neoplasm · score 0.09
- acute myocardial infarction · score 0.08
- acute myeloid leukemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXA8-F1 | alphafold | PREDICTED | 89.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXA8.
Amino-acid sequence (310 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRT5?
The strongest Open Targets associations for SIRT5 are lymphocyte count, platelet count, lymphocyte percentage of leukocytes, neutrophil percentage of leukocytes and aspartate aminotransferase measurement.
How long is the SIRT5 protein?
The Homo sapiens SIRT5 protein (UniProt Q9NXA8) is 310 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXA8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXA8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.