Tectonic-like complex member MKS1 (MKS1)
Homo sapiens — UniProt Q9NXB0
Data last refreshed: (UniProt release unknown)
Key facts
Tectonic-like complex member MKS1 (MKS1) is a protein from Homo sapiens identified by UniProt accession Q9NXB0, 559 residues long. MolForge cross-references it against 0 known binders and 222 disease associations.
- UniProt accession: Q9NXB0; gene symbol MKS1.
- Organism: Homo sapiens.
- Length: 559 amino acids.
- Top disease associations (Open Targets): Meckel syndrome, Joubert syndrome and Bardet-Biedl syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tectonic-like complex member MKS1 |
|---|---|
| UniProt accession | Q9NXB0 |
| Gene | MKS1 |
| Organism | Homo sapiens |
| Length | 559 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (222)
Diseases linked to this target (Open Targets).
- Meckel syndrome · score 0.76
- Joubert syndrome · score 0.76
- Bardet-Biedl syndrome · score 0.76
- polydactyly · score 0.66
- Polydactyly · score 0.54
- Polycystic kidney dysplasia · score 0.53
- occipital encephalocele · score 0.53
- renal fibrosis · score 0.53
- genetic disorder · score 0.45
- Nystagmus · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXB0-F1 | alphafold | PREDICTED | 73.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXB0.
Amino-acid sequence (559 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MKS1?
The strongest Open Targets associations for MKS1 are Meckel syndrome, Joubert syndrome, Bardet-Biedl syndrome, polydactyly and Polydactyly.
How long is the MKS1 protein?
The Homo sapiens MKS1 protein (UniProt Q9NXB0) is 559 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXB0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXB0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.