Myotubularin-related protein 10 (MTMR10)

About Myotubularin-related protein 10

Myotubularin-related protein 10 (MTMR10) is a protein from Homo sapiens identified by UniProt accession Q9NXD2, 777 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Myotubularin-related protein 10
UniProt accession	Q9NXD2
Gene	MTMR10
Organism	Homo sapiens
Length	777 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
Alzheimer disease · score 0.40
multiple sclerosis · score 0.40
lysosomal storage disease · score 0.40
Parkinson disease · score 0.40
karyomegalic interstitial nephritis · score 0.12
PHF-tau measurement · score 0.06
protein measurement · score 0.06
Abnormality of refraction · score 0.06
sunburn · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NXD2-F1	alphafold	PREDICTED	78.80	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXD2.

Amino-acid sequence (777 residues)

MFSLKPPKPT FRSYLLPPPQ TDDKINSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY VGKKYHNSAN KINGIPSGDG GGGGGGGNGA GGGSSQKTPL FETYSDWDRE IKRTGASGWR VCSINEGYMI STCLPEYIVV PSSLADQDLK IFSHSFVGRR MPLWCWSHSN GSALVRMALI KDVLQQRKID QRICNAITKS HPQRSDVYKS DLDKTLPNIQ EVQAAFVKLK QLCVNEPFEE TEEKWLSSLE NTRWLEYVRA FLKHSAELVY MLESKHLSVV LQEEEGRDLS CCVASLVQVM LDPYFRTITG FQSLIQKEWV MAGYQFLDRC NHLKRSEKES PLFLLFLDAT WQLLEQYPAA FEFSETYLAV LYDSTRISLF GTFLFNSPHQ RVKQSTEFAI SKNIQLGDEK GLKFPSVWDW SLQFTAKDRT LFHNPFYIGK STPCIQNGSV KSFKRTKKSY SSTLRGMPSA LKNGIISDQE LLPRRNSLIL KPKPDPAQQT DSQNSDTEQY FREWFSKPAN LHGVILPRVS GTHIKLWKLC YFRWVPEAQI SLGGSITAFH KLSLLADEVD VLSRMLRQQR SGPLEACYGE LGQSRMYFNA SGPHHTDTSG TPEFLSSSFP FSPVGNLCRR SILGTPLSKF LSGAKIWLST ETLANED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards