Sphingomyelin phosphodiesterase 4 (SMPD4)
Homo sapiens — UniProt Q9NXE4
Data last refreshed: (UniProt release unknown)
Key facts
Sphingomyelin phosphodiesterase 4 (SMPD4) is a protein from Homo sapiens identified by UniProt accession Q9NXE4, 866 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9NXE4; gene symbol SMPD4.
- Organism: Homo sapiens.
- Length: 866 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingomyelin phosphodiesterase 4 |
|---|---|
| UniProt accession | Q9NXE4 |
| Gene | SMPD4 |
| Organism | Homo sapiens |
| Length | 866 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies · score 0.72
- neurodegenerative disease · score 0.44
- genetic disorder · score 0.41
- type 1 diabetes mellitus · score 0.19
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- partial chromosome Y deletion · score 0.05
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
- spermatogenic failure 61 · score 0.05
- spermatogenic failure 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXE4-F1 | alphafold | PREDICTED | 71.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXE4.
Amino-acid sequence (866 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMPD4?
The strongest Open Targets associations for SMPD4 are neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies, neurodegenerative disease, genetic disorder, type 1 diabetes mellitus and azoospermia.
How long is the SMPD4 protein?
The Homo sapiens SMPD4 protein (UniProt Q9NXE4) is 866 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXE4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXE4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.